Cobalamin Deficiency in Elderly Patients: A Personal View

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Cobalamin Deficiency in Elderly Patients: A Personal View

Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-co...

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Vitamin B12 (cobalamin) deficiency in elderly patients.

Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%...

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Prevalence of cobalamin deficiency in the Framingham elderly population.

To determine whether the increased prevalence of low serum cobalamin concentrations in elderly people represents true deficiency, serum concentrations of cobalamin and folate and of metabolites that are sensitive indicators of cobalamin deficiency were measured in 548 surviving members of the original Framingham Study cohort. Serum cobalamin concentrations < 258 pmol/L were found in 222 subject...

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Relationship between cobalamin deficiency and delirium in elderly patients undergoing cardiac surgery

BACKGROUND Delirium is common after cardiac surgery and is independently associated with increased morbidity, mortality, prolonged hospital stays, and higher costs. Cobalamin (vitamin B12) deficiency is a common cause of neuropsychiatric symptoms and affects up to 40% of elderly people. The relationship between cobalamin deficiency and the occurrence of delirium after cardiac surgery has not be...

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The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Until the 1990s, the most common recognised cause of cobalamin deficiency in adults was pernicious anaemia [1]. Thanks to progress made during the last 10-20 years in the understanding of vitamin B12 metabolism, “new” physiopathological concepts have emerged or recognized, including a controversial medical concept entitled food-cobalamin malabsorption (FCM) in Anglo-Saxon literature, also known...

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ژورنال

عنوان ژورنال: Current Gerontology and Geriatrics Research

سال: 2008

ISSN: 1687-7063,1687-7071

DOI: 10.1155/2008/848267